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KMID : 0377619680150040283
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Korean Jungang Medical Journal
1968 Volume.15 No. 4 p.283 ~ p.288
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On The Effects of Anti-Tumor Agents on Lactic Dehydrogenase Isozymes of Sarcoma-180 Ascites Cells
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Abstract
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1) The author in the present paper, investigated the inhibitory effects of 6-mercapto-purine and 5-fluorouracil on the activities of lactic dehydrogenase and its isozymes, H-and M-LDH respectively, to find out that these anti-tumor agents exerted selective action towards the 2 isozymes.
2) Both of the agents inhibited the activity of LDH of the Sarcoma-180 ascites cells, the effect exerted by 5-fluorouracil being far greater than the effect displayed by 6-mercaptopurine.
3) Both of the agents showed the inhibitory effects on the LDH isozymes, but the inhibition of M-LDH was more pronounced than the inhibition of H-LDH by both of the agents.
4) 5-Fluorouracil showed more marked inhibitory effect on the M-LDH than 6-Mercaptopurine.
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KEYWORD
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